2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0150S2
    Nicotinamide-13C6 2749910-55-0 99.8%
    Nicotinamide-13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
    Nicotinamide-13C6
  • HY-B0405AR
    Bupivacaine hydrochloride (Standard) 18010-40-7 99.99%
    Bupivacaine (hydrochloride) (Standard) is the analytical standard of Bupivacaine (hydrochloride). This product is intended for research and analytical applications. Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain.
    Bupivacaine hydrochloride (Standard)
  • HY-B0546AR
    Procaine hydrochloride (Standard) 51-05-8 99.75%
    Procaine (hydrochloride) (Standard) is the analytical standard of Procaine (hydrochloride). This product is intended for research and analytical applications. Procaine hydrochloride is a DNA-demethylating agent. Procaine hydrochloride acts through multiple targets and has a slow onset and a short duration of action.
    Procaine hydrochloride (Standard)
  • HY-N0138S1
    Theobromine-d3 65566-69-0 99.78%
    Theobromine-d3 is the deuterium labeled Theobromine. Theobromine is a methylxanthine found in cacao beans which can inhibit adenosine receptor A1 (AR1) signaling.
    Theobromine-d3
  • HY-N0390S4
    L-Glutamine-5-13C 159680-32-7 98.0%
    L-Glutamine-5-13C is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
    L-Glutamine-5-13C
  • HY-W005637
    Orthocaine 536-25-4 99.81%
    Orthocaine is a local agent that can suppress or relieve pain (extracted from patent WO2002089849A1).
    Orthocaine
  • HY-W009970
    N-Benzylglycine ethyl ester 6436-90-4
    N-Benzylglycine ethyl ester is an N-substituted glycine derivative. N-Benzylglycine ethyl ester is bound to PDB code: 1B41. N-Benzylglycine ethyl ester can be used in Alzheimer's disease research.
    N-Benzylglycine ethyl ester
  • HY-W010513
    3-Methylvaleric Acid 105-43-1 99.99%
    3-Methylvaleric Acid is a branched alkanoic acid. 3-Methylvaleric Acid can be utilized by Pseudomonas citronettotis as a sole carbon source for its growth. 3-Methylvaleric Acid derivatives exhibit anti-hyperalgesic and anticonvulsant activities.
    3-Methylvaleric Acid
  • HY-W012206
    (Rac)-Metanephrine hydrochloride 881-95-8 99.84%
    (Rac)-Metanephrine hydrochloride is a metabolite of epinephrine and a substrate of the sulfotransferase SULT1A3. (Rac)-Metanephrine hydrochloride undergoes sulfonation at its p-hydroxyl group via a reaction catalyzed by SULT1A3. (Rac)-Metanephrine hydrochloride is an isomer of Metanephrine (HY-113299) hydrochloride, and it is applicable to the research of pheochromocytoma.
    (Rac)-Metanephrine hydrochloride
  • HY-W012735
    (+)-Nipecotic acid 59045-82-8 ≥98.0%
    (+)-Nipecotic acid ((+)-β-Homoproline) is a GABA transport inhibitor with potential antidepressant and anxiolytic activities. (+)-Nipecotic acid can increase the concentration of GABA in the synaptic cleft, thereby enhancing inhibitory neurotransmission. The research on (+)-Nipecotic acid provides a possible direction for the development of new inhibitory compounds for psychiatric diseases.
    (+)-Nipecotic acid
  • HY-W014325
    TRPM8 agonist WS-3 39711-79-0 99.35%
    TRPM8 agonist WS-3 is an specific agonist of TRPM8 with an EC50 of 3.7 μM. TRPM8 agonist WS-3 inhibits epileptic seizures through a TRPM8 dependent mechanism. TRPM8 agonist WS-3 can be used for research on epilepsy and other conditions.
    TRPM8 agonist WS-3
  • HY-W015050
    1-Anthramine 610-49-1 98.74%
    1-Anthramine (1-aminoanthracene) is a fluorescent general anesthetic. potentiates GABAergic transmission with Kd = 0.1 mM, for binding to the general anesthetic site in horse spleen apoferritin (HSAF). 1-Anthramine fluorescence is enhanced when bound to HSAF. 1-Anthramine potentiates chloride currents elicited by GABA. 1-Anthramine can reversibly inhibit the movement of Xenopus laevis, with an EC50 value of 16 μM.
    1-Anthramine
  • HY-W016289
    Antiarol 642-71-7 99.98%
    Antiarol (3,4,5-Trimethoxyphenol) is a phenolic compound present in the trunk of Coffea canephora. Antiarol is a metabolite produced by chicken cecal microbes, whose cecal content changes dynamically with the severity of wooden breast (WB; a muscle disease prevalent in broilers) and enters the plasma through circulation.
    Antiarol
  • HY-W022047
    nNOS-IN-1 945762-00-5 99.53%
    nNOS-IN-1(Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC50s of 2.5, 5.7 and 13 μM, respectively.
    nNOS-IN-1
  • HY-W042214
    Ritalinic acid 19395-41-6 99.81%
    Ritalinic acid (Ritalinate) is a metabolite of Methylphenidate. Ritalinic acid has no biological activity or only extremely low biological activity. The concentration of Ritalinic acid detected in university campus sewage shows a gradual upward trend in the first semester, while no obvious periodic variation pattern related to academic stress is observed in the second semester. Ritalinic acid can be used in studies related to attention deficit disorder, narcolepsy, depression and attention deficit hyperactivity disorder.
    Ritalinic acid
  • HY-W099757
    (±)-Coniine hydrochloride 15991-59-0 98.0%
    (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg.
    (±)-Coniine hydrochloride
  • HY-W203728
    L-β-Imidazolelactic acid 14403-45-3 99.93%
    L-β-Imidazolelactic acid is a histidine derivative and an oxidizing agent that can trigger antioxidant effects in the brain cortex of rats.
    L-β-Imidazolelactic acid
  • HY-W344044
    Levomepromazine maleate 7104-38-3 99.92%
    Levomepromazine maleate (Methotrimeprazine maleate) is an N-substituted phenylthiazine antipsychotic sedative that blocks multiple receptors. Levomepromazine maleate is a potent inhibitor of CYP2D6 and is useful in the study of schizophreni.
    Levomepromazine maleate
  • HY-W750342
    Tryptophol-d4 75238-45-8 99.97%
    Tryptophol-d4 (Indole-3-ethanol-d4) is the deuterium labeled Tryptophol (HY-W010155). Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy.
    Tryptophol-d4
  • HY-Y0966S7
    Glycine-2-13C,15N 91795-59-4 98.0%
    Glycine-2-13C,15N is the 13C- and 15N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
    Glycine-2-13C,15N
Cat. No. Product Name / Synonyms Application Reactivity